Carlos Bolaños Guzman, Ph.D.
Ph.D. Northeastern University
Dr. Bolaños research aims at establishing causal relationships between early-life experiences, brain, biochemistry, and behavior. Specifically, his research interest center on investigating how exposure to psychotropic drugs (e.g. stimulants, antidepressants, prescription drugs), and stress (whether physical or emotional), alter the biochemical integrity of neuronal pathways involved in the regulation of mood and motivated behaviors, and how these pharmacological, environmental, and/or genetic manipulations early-in-life affect biochemical and behavioral functioning later in adulthood. Understanding the relationship(s) between brain and behavior from a developmental perspective can provide novel insights for the development of therapeutics for stress and drug dependence. Dr. Bolaños’ work is funded by the National Institute on Drug Addiction (NIDA).
Parise EM, Bolaños CA. Chronic Social Defeat and Intracranial Self-Stimulation: Unmasking the Many Faces of Depression?. Biol Psychiatry. 76(7): 513-514. (2014)
Iñiguez SD, Alcantara LF, Warren BL, Riggs LM, Parise EM, Vialou V, Wright KN, Dayrit G, Nieto SJ, Wilkinson MB, Lobo MK, Neve RL, Nestler EJ, Bolaños CA. Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood.. J Neurosci. 34(3): 1007-1021. (2014)
Warren BL, Sial OK, Alcantara LF, Greenwood MA, Brewer JS, Rozofsky JP, Parise EM Bolaños CA. Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress.. Dev Neurosci.. 36(3-4): 250-260. (2014)
Alcantara LF, Warren BL, Parise EM, Iñiguez SD, Bolaños CA. Effects of psychotropic drugs on second messenger signaling and preference for nicotine in juvenile male mice.. Psychopharmacology. 231(8): 1479-1492. (2014)
Parise EM, Alcantara LF, Warren BL, Wright KN, Hadad R, Sial OK, Kroeck KG, Iñiguez SD, Bolaños CA. Repeated ketamine exposure induces an enduring resilient phenotype in adolescent and adult rats.. Biol Psychiatry. 74(10): 750-759. (2013)
Iñiguez SD, Charntikov S, Baella SA, Herbert MS, Bolaños-Guzmán CA, Crawford CA. Post-training cocaine exposure facilitates spatial memory consolidation in C57BL/6 mice. Hippocampus. in press. (2011)
Warren BL†, Iñiguez SD†, Alcantara LF, Wright KN, Parise EM, Weakley SK, Bolaños-Guzmán CA. Juvenile administration of concomitant methylphenidate and fluoxetine alters behavioral reactivity to reward- and mood-related stimuli and disrupts ventral tegmental area gene expression in adulthood. J Neurosci. 31(28): 10347-10358. (2011) [†Authors contributed equally to this work]
Iñiguez SD, Warren BL, Bolaños-Guzmán CA. Short- and Long-term Functional Consequences of Fluoxetine Exposure During Adolescence in Male rats. Biol Psychiatry. 67(11):1057-1066. (2010)
Iñiguez SD, Vialou V, Warren BL, Cao JL, Alcantara LF, Davis LC, Manojlovic Z, Neve RL, Russo SJ, Han MH, Nestler EJ, Bolaños-Guzmán CA. Extracellular Signal-Regulated Kinase-2 Within the Ventral Tegmental Area Regulates Responses to Stress. J Neurosci. 30(22):7652-7663. (2010)
Vialou V, Robison AJ, LaPlant QC, Covington III HE, Dietz DM, Ohnishi YN, Mouzon E, Rush III AJ, Watts EL, Wallace DL, Iñiguez SD, Ohnishi YH, Steiner MA, Warren BL, Krishnan V, Bolaños CA, Neve RL, Ghose S, Berton O, Tamminga CA, Nestler EJ. DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci. 13(6):745-752. (2010)